...
【24h】

Measurement of oedema in irritant-exposed skin by a dielectric technique.

机译:通过电介质技术测量暴露于刺激物的皮肤中的水肿。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

Background: Easily applicable water-specific instruments measuring local oedema in skin are not available. The aim of this study is to demonstrate quantitative assessment of skin oedema with the dielectric technique by measuring increase of skin water content related to sodium lauryl sulphate (SLS)-induced irritant contact dermatitis. Methods: Irritant skin reaction and resulting oedema were induced by an irritant patch test on volar forearms in 12 healthy volunteers with the application of 1% SLS for 6 h. After occlusion the volunteers were divided into two groups: the patch test site of group I (six volunteers) received no treatment other than a base cream for the skin reaction, while for group II (six volunteers) a strong corticosteroid (clobetasol propionate) was applied on the irritant skin. During a follow-up of 72 h, erythema was scored visually, and irritant-induced oedema was measured with a novel water-specific instrument MoistureMeter-D. Results: In the untreated irritant skin, a maximum increase of 45% in skin water content was found at 10 h postocclusion and water content was still elevated at 72 h. With these persons, the degree of oedema agreed well with the ultrasound-measured skin thickness (P=0.053). In the corticosteroid-treated skin, an increase of 8% in water content was measured during 72 h but there was no correlation between oedema and skin thickness. There was no correlation between erythema and oedema in untreated or corticosteroid-treated skin. Conclusion: The new instrument can easily be applied for noninvasive quantitative evaluation of local oedema and fluid retention in irritant-exposed skin.
机译:背景:尚无可用于测量皮肤局部水肿的易于使用的水专用仪器。这项研究的目的是通过测量与月桂基硫酸钠(SLS)引起的刺激性接触性皮炎有关的皮肤水分含量的增加,通过介电技术证明对皮肤水肿的定量评估。方法:采用1%SLS刺激12名健康志愿者,对12名健康志愿者的掌前臂进行刺激性斑贴试验,引起皮肤刺激性反应和由此产生的水肿。闭塞后,将志愿者分为两组:第一组(六名志愿者)的斑贴试验部位除针对皮肤反应的基础霜外未接受任何治疗,而第二组(六名志愿者)的强效皮质类固醇(丙酸氯倍他索)为适用于刺激性皮肤。在72小时的随访过程中,目视对红斑进行评分,并使用新型水特异性仪器MoistureMeter-D测量刺激物引起的水肿。结果:在未经处理的刺激性皮肤中,闭塞后10 h皮肤含水量最大增加了45%,而72 h含水量仍然增加。对于这些人,水肿程度与超声测得的皮肤厚度非常吻合(P = 0.053)。在皮质类固醇治疗的皮肤中,在72小时内测得水分含量增加了8%,但水肿与皮肤厚度之间没有相关性。未经治疗或经皮质类固醇治疗的皮肤中红斑和水肿之间没有相关性。结论:该新仪器可轻松用于无刺激性定量评估暴露于刺激性皮肤的局部水肿和积水。

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号