Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK

摘要

Studies of the non-selective NaK channel as a model system provided detailed structural and functional insights into different factors that modulate selective ion conductance. The combination of structural and functional studies of WT- and mutant forms of NaK channel show that apparent conservation of the multiple binding sites in the canonical selectivity filter of K-channel is essential component of the observed robust Na+ discrimination.