The Conformation of B18 Peptide in the Presence of Fluorinated and Alkylated Nanoparticles

摘要

The misfolding and aggregation of proteins into amyloid fibrils are thought to be the cause of various neurological and systemic diseases.Amyloid fibrils consist of polypeptide chains organized into beta-sheets.In contrast,the secondary structure of the native proteins is dominated by alpha-helical and random-coil conformations.Therefore,the inhibition of conformational transitions and subsequent fibril formation constitute a possible approach for preventing the progression of amyloid-related diseases.