Elucidation of the Glycosylation Sequence of Mithramycin Biosynthesis:Isolation of 3A-Deolivosylpremithramycin B and Its Conversion to Premithramycin B by Glycosyltransferase MtmGII

摘要

Mithramycin(MTM)is an aureolic acid-type polyketide produced by various soil bacteria of the genus Streptomyces including Streptomyces argillaceus(ATCC 12956).MTM has been used clinically to treat Paget's disease and testicular carcinoma,and MTM's hypocalcemic effect has been used to manage hypercalcemia in patients with malignancy-associated bone lesions.Mithramycin has also been shown to act as neuroprotective drug.