Determination of Atenolol in Pure Substance and Pharmaceutical Preparations Applying First Order Derivative Spectrophotometry

摘要

The improved first order derivative spectrophotometric method for the determination of atenolol in pure substance and pharmaceutical preparations has been proposed.The first order derivative spectrum of the coloured complex of atenolol with phenolsulfothaline exhibited maximum absorbance at 558.4 nm.The proposed approach allowed one to eliminate spectral interferences.The measured analytical signal changed linearly within the analyte concentration range: from 0.05 to 0.4 mg mL~(-1).Coefficient of variation was 0.854%.Detection limit was found to be 0.05 mg mL~(-1).