Graphite-coated magnetic nanoparticles as multimodal imaging probes and cooperative therapeutic agents for tumor cells

摘要

Carbon-protected iron cobalt nanoparticles (FeCo/C NPs) are synthesized using a hydrothermal approach. It is demonstrated that FeCo/C NPs can be used as highly sensitive magnetic resonance and Raman imaging probes. These FeCo/C NPs are then used for targeting tumor cells for combined siRNA and hyperthermia-based therapy, resulting in the significant inhibition of proliferation and induction of apoptosis in tumor cells.