Control of depolarization-evoked presynaptic neurotransmitter release by Ca(V)2.1 calcium channel

摘要

In mouse chromaffin cells Ca(V)1.3 is coupled to fast-inactivating BK channels within membrane nanodomains and controls AP repolarization. The ability to carry subthreshold Ca2+ currents and activate BK channels confers to Ca(V)1.3 the unique feature of driving Ca2+ loading during long interspike intervals and, possibly, to control the Ca2+-dependent exocytosis and endocytosis processes that regulate catecholamine secretion and vesicle recycling.