Total Synthesis and Proof of Stereochemistry of Natural and Unnatural pinnaic Acids: A Remarkable Long-Range Stereochemical Effect in the Reduction of 17-Oxo Precursors of the Pinnaic Acids

摘要

The extraordinary powers of spectroscopic methods and crystallography in elucidating structural, configurational, and conformational issues of small as well as larger (bio size) molecules are well appreciated by practicing chemists. It is rare that total synthesis contributes to the process of structural determination of natural products.