BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery

摘要

TGF-beta regulates tissue fibrosis: TGF-beta promotes fibrosis, whereas bone morphogenetic protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after pressure overload is associated with disequilibrium in the signalling mediated by these cytokines, and (ii) BMP-7 exerts beneficial effects on LV remodelling and reverse remodelling.