Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress

摘要

Aims Myofibroblasts (MFBs) as appearing in themyocardium during fibrotic remodelling induce slow conduction following heterocellular gap junctional coupling with cardiomyocytes(CMCs) in bioengineered tissue preparations kept under isometric conditions. In this study, we investigated the hypothesis that strain as developed during diastolic filling of the heart chambers may modulate MFB-dependent slow conduction.