Osteopontin: An emerging therapeutic target in uraemic vascular disease

摘要

The incidence of cardiovascular disease remains high in the population with renal failure and constitutes the leading cause of morbidity and mortality in these patients. According to the U.S. Renal Data System 2011 Annual Data Report, the rate of death among dialysis patients attributable to cardiovascular disease was 40% and 5% to acute myocardial infarction. However, the mechanisms by which renal failure accelerates development of vascular disease and magnifies cardiovascular morbidity and mortality remain elusive.