Regulation of JAK/STAT signalling by SOCS in the myocardium

摘要

In the myocardium, cytokines are activated in response to acute and chronic cardiac stresses. Some of them, including the interleukin (IL)-6 family of cytokines, have been implicated in cardioprotection, cardiac hypertrophy, inflammation, and heart failure via activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway (Figure 1).Much effort has been made to explore the physiological/pathophysiological functions and mechanisms of positive regulation of the JAK/STAT signalling pathway in cardiac disease. Recent research has placed increasing emphasis on the termination of the signals by suppressors of cytokine signalling (SOCS) proteins. In the current issue of Cardiovascular Research, Cittadini et ol.