Managing treatment side effects in advanced breast cancer.

摘要

OBJECTIVES: To compare and contrast the side-effect profiles of antineoplastic therapy options used in the treatment of metastatic breast cancer. DATA SOURCES: Published research articles, abstracts, and clinical experience. CONCLUSION: Novel and existing antineoplastic agents used in the treatment of metastatic breast cancer generally have mild side effects, but can have the potential for serious reactions. Nausea/vomiting, diarrhea, stomatitis/mucositis, and dermatologic and cardiovascular effects are common. Strategies such as dietary changes, over-the-counter remedies, and dose modification can be used to counteract these mild effects. IMPLICATIONS FOR NURSING PRACTICE: The oncology nurse should be aware of common adverse events associated with antineoplastic agents, recognize early side-effect signs, and be ready with effective strategies to mitigate side effects when and if they occur.