Baseline serum urate and 90-day functional outcomes following acute ischemic stroke.

摘要

It is increasingly recognized that there is an association between elevated serum urate and cardiovascular morbidity and mortality [1, 2]. This relationship is consistently apparent in cohorts with vascular risk factors and those with established cardiovascular disease. However, the situation is less clear in the acute period after stroke. Some studies show that increasing serum urate levels link with worse outcome [3] and risk of early clinical deterioration [4] while others report a link with good outcome [5]. There are biological reasons for and against a beneficial effect of urate in the peri-infarct period but unfortunately available evidence does not allow us to draw conclusions either way. Also, no study has evaluated the association with 90-day functional outcome, the standard used in clinical trials. We explored this association using data from the Virtual International Stroke Trials Archive (VISTA) [6] resource.