Substantial evidence for colorectal cancer reduction with daily low-dose aspirin.

摘要

High-dose aspirin (> 500 mg daily) taken for a period of five years has been shown in long-term follow-up studies to reduce the risk of colorectal cancer in the next decades of the patient's life. However, the greater risk of bleeding complications at this high dose reduces aspirin's potential in primary prevention of cancers.New data from four trials of aspirin,1 using dally dosages from 75 to 300 mg were compared to the high-dose aspirin studies and showed:75 mg aspirin taken daily is as effective as high-dose aspirin in reducing the 20-year incidence of colorectal cancer (by 30%) if taken for approximately five years.