Simultaneous treatment of blood pressure and cholesterol beats the 'SILO' approach in lowering cardiovascular risk: results of the CRUCIAL study.

摘要

The so-called 'SILO' treatment approach based on the visualisation of individual cardiovascular risk factors and resulting in one-at-a-time risk-factor treatment is less effective than the simultaneous targeting of the two major risk factors, blood pressure and cholesterol.This has been shown in the CRUCIAL (Cluster Randomised Usual Care versus Caduet Investigation Assessing Long-term risk) study of moderately at-risk patients with no prior history of coronary heart disease (CHD) in which proactive, simultaneous treatment of blood pressure and cholesterol using a single pill (amlodipine/atorvastatin) was compared to usual care.