Candida albicans meningitis in a 27 weeks premature infant treated with liposomal amphotericin-B (AmBisome)

摘要

We report a case of Candida albicans meningitis in a neonate born after 27 weeks of gestation. To the best of our knowledge this is the first report of a premature infant with Candida-meningitis treated with liposomal amphotericin B (AmBisome(R)). The patient did not respond well to conventional Amphotericin B, but was successfully cured with Ambisome(R). Liposomal amphotericin B was well tolerated and the baby recovered with a postinfectious hydrocephalus which necessitated a permanent ventriculo-peritoneal shunt. Six months after the infection the baby appears to have a near-normal cerebral development.