Particulate beta-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells

摘要

Scope: The major receptor for beta(1-3)-glucans on immune cells is considered to be Dectin-1 receptor. Particulate beta-glucans induce stronger immune responses than soluble beta-glucans by clustering of Dectin-1 receptors. Here, it was hypothesized that activation of other pattern recognition receptors such as Toll-like receptor 4 (TLR4) can also contribute to enhanced activity of immune cells after exposure to particulate beta-glucans.