The Influence of Immunoregulatory Cytokines IL-2, IL-7, and IL-15 upon Activation, Proliferation, and Apoptosis of Immune Memory T-cells in vitro

摘要

The influence of immunoregulatory cytokines IL-2, IL-7, and IL-15 on the activation, proliferation, and apoptosis of different subpopulations of an immune memory T-cell (CD45RO+) in healthy donors were investigated. It was demonstrated that rIL-2 equally affected both the activation and proliferation of CD4~+ and CD8~+ subpopulations of memory T-cells in vitro. High concentrations of rIL-2 increased the number of CD8~+ memory cells expressing apoptotic marker CD95. Effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic CD8~+ memory cells in vitro was different. CD4~+ memory lymphocytes exhibited relative resistance to activation and proliferation by rIL-7 and rIL-15 compared to rIL-2. This can provide them with relative resistance to apoptosis, as well as create the necessary conditions for accelerated implementation of their functional capacity in the development of a secondary immune response.