Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

摘要

Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, ~1H and ~(13)C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P21 with unit cell dimensions a = 11.7752(6) A, b= 3.8677(2) A, c= 27.4126(13) A and β = 92.734(5) A. There is a strong intramolecular hydrogen bond of the type N__H···O, with H···O distance of 2.5869(19) A. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity.