A case of autoimmune polyglandular syndrome type III with a slowly progressive form of type-1 diabetes mellitus that manifested in the course of autoimmune diseases

摘要

Autoimmune polyglandular syndrome (APS) is a group of disorders with multiple autoimmune endo-crinopathies. Although the exact cause is not clear, genetic background and autoimmunity are known to be associated with its pathogenesis. There are three types of APS, some of which are often complicated by type-1 diabetes mellitus or Sjogren's syndrome. However, Sjogren's syndrome is an autoimmune exocrinopathy and is also complicated by various autoimmune disorders. Here we present a rare case of APS type III with a slowly progressive form of type-1 diabetes mellitus complicated.by Sjogren's syndrome, autoimmune thyroiditis, and probable systemic lupus erythematosus.