Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis: comments on the article by Dong et al.

摘要

We read with great interest the article by Dong et al on 'Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis' (1). In this work, Dong et al found that the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 (GRP78) is highly expressed in macrophages in the affected peripheral joints of ankylosing spondylitis (AS) compared with osteoarthritis (OA) patients. In addition, positive correlations were found between the expression of GRP78 in macrophages in AS-affected peripheral joints and the syno-vial fluid levels of tumour necrosis factor (TNF)-a and interleukin (IL)-6.