HYDROAMINATION OF ALKENES

摘要

Generous financial support by the National Science Foundation through a NSF CAREER Award (CHE 0956021) and the ACS Petroleum Research Fund (PRF #49109-ND1) is gratefully acknowledged. The development of efficient synthetic procedures for establishing carbon-nitrogen bonds has received significant attention over the last one and a half centuries, due to the importance of nitrogen-containing compounds in biological systems and pharmaceutical applications.1'2 Although a large number of carbon-nitrogen bond-forming processes have been devised during this period, the hydroamination of alkenes represents, in principle, one of the most attractive and efficient routes. The catalytic hydroamination of alkenes, allenes, and dienes leads to amines, imines, and enamines. (Scheme 1). The reactions may also be performed in an intramolecular fashion.