HYDROGEN-BONDING-MEDIATED DIRECTED OSMIUM DIHYDROXYLATION

摘要

This review focuses on the dihydroxylation of alkenes using osmium tetroxide (OSO4) that is directed by alcohols and amine derivatives through hydrogen bonding between the substrate and the oxidant. Discussion focuses on the different types of directing groups that are viable. The outcome from directed dihydroxylation of all the major classes of alkenes, including cyclic and acyclic substrates and varied alkene substitution patterns, is also addressed (Eqs. 1 and 2).