Discussion Addendum for: preparation of α-Acetoxy Ethers by the Reductive Acetylation of Esters: endo-1-Bornyloxyethyl Acetate

摘要

Reductive acetylation has proven to be a powerful methodology primarily because its products are excellent substrates for carbon-carbon bond forming reactions. Since 2003, the Organic Syntheses article and the primary references have been cited over 100 times. This discussion addendum aims to provide a brief overview of recent developments in this methodology. Improvements and variations of α-acetoxy ether formation, as well as the synthetic utility of a-acetoxy ethers will be discussed. Recent applications in the context of the total synthesis of complex natural products are also included.