Phase-Transfer Catalyzed Asymmetric Conjugate Additions of β-Ketoesters to Acetylenic Ketones

摘要

Asymmetric conjugate addition of cyclic β-keto esters to acetylenic ketones has been achieved with high enantioselectivity and moderate Ell selectivity under the influence of a binaphthyl-modified 3,5-bis[3,5-bis(trifluoromethyl)phenyl]phenyl-substituted phase-transfer catalyst.