Rapid Improvement of a Reductive Sulfonylation Using Design of Experiment Methods

摘要

Sulfone 2 was initially prepared using a zinc-mediated one-pot coupling procedure. A traditional sodium sulfite-mediated two-pot procedure was found to eliminate a major impurity, yet modest yields prevailed. Design of experiment methods with the aid of a basic parallel synthesizer rapidly led to a high-yielding one-pot process.