Development of the Process of p-Nitroacetophenone and Benzoic Acid Manufacture by the Liquid-Phase Oxidation of Aromatic Compounds

摘要

The kinetic model of the ethyl benzene oxidation was applied to the design of the large-scale reactors of p-nitroacetophenone (chloramphenicol key intermediate) synthesis by p-nitroethyl benzene oxidation and benzoic acid synthesis by acetophenone oxidation. The factors allowing simplification of the above model are discussed. The height of the frothy (aerated) liquid layer in the oxidation tower securing the explosion-proof reaction conditions of acetophenone and p-nitroethyl benzene oxidation both in the kinetic and diffusion fields was calculated.