Particle Shape Characterisation via Image Analysis:from Laboratory Studies to In-process Measurements Using an in Situ Particle Viewer System

摘要

A recent evaluation of a new in situ particle viewer(ISPV)system for the examination of particle shape and its subsequent development during crystal growth is presented.Precharacterization studies using conventional and hot-stage microscopy reveal that the ISPV probe system together with a commercial image analysis software is capable of generating representative high-quality images which can be processed and analysed.ISPV studies of the batch crystallization of L-glutamic acid in a 20-L reactor are shown to be able to characterise effectively crystallization and polymorphic phase transformation processes,revealing potential applications in both small-and large-scale reactor systems.Some improvements to the probe,such as increasing the resolution and reducing the encrustation using thermal coating,are suggested.