Reduced oxygenation and erythropoietin [Review] [German]

摘要

Reduced oxygenation activates specific expression of erythropoietin (EPO) and other hypoxia-regulated genes. The cellular response to hypoxia is mediated by the hypoxia-inducible factor-1 (HIF-1). Unregulated overexpression of EPO results in a hematocrit value of about 80%; transgenic mice were shown to adapt to this polyglobulia.