A novel Mn(II) complex with 3-(2,5-dicarboxyl)-5-carboxylpyridine: Synthesis, crystal structure, and interaction with DNA

摘要

A novel Mn coordination polymer, {[Mn-2(L)(6)] center dot 2H(2)O} (n) , has been synthesized by the reaction of C4H6MnO4 center dot 4H(2)O (manganese acetate) with 3-(2,5-dicarboxyl)-5-carboxylpyridine (L). Elemental analysis, IR spectra, thermal analyses, and X-ray single crystal diffraction (CIF file CCDC no. 1061752) were carried out to determine the composition and crystal structure of the complex. The polymer was characterized by UV spectrum, fluorescence spectrum showing that the complex has the ability of interaction with DNA, Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA (HL-60 DNA, which was extracted by ourselves). Further more, the apoptotic test indicates that the complex has an apoptotic effect on JEKO.