Replication of Han Chinese GWAS loci for schizophrenia via meta-analysis of four independent samples

摘要

Schizophrenia is a highly heritable psychiatric disorder with unclear aetiology. Recent genome-wide association studies (GWAS) in European populations have reported numerous susceptibility variants, while GWAS in East Asians also identified several risk loci but with fewer independent replications. Here we focus on nine single nucleotide polymorphisms (SNPs) which have shown genome-wide significant associations with schizophrenia in previous Han Chinese GWAS, and we tend to replicate the associations in four independent samples of East Asian origin including a total of 3977 cases and 5589 controls. The results showed that rs10489202 in MPC2 (BRP44) is significantly associated with schizophrenia in these East Asian replication samples (one-tailed P = 5.75 x 10(-3), OR = 1.12), and further meta-analysis after including previous GWAS data yielded a genome-wide significant association (two-tailed P = 1.11 x 10(-10), OR = 1.19), adding further support for the involvement of this locus in the genetic risk of schizophrenia, and future studies regarding the underlying molecular mechanisms of the risk association are necessary. (C) 2016 Elsevier B.V. All rights reserved.