Medial prefrontal cortical activation during working memory differentiates schizophrenia and bipolar psychotic patients: a pilot FMRI study.

摘要

Kraepelin's differentiation of the major psychoses into Schizophrenia and "Manic-Depressive Insanity" (Bipolar Disorder) as distinct neuropsychiatric disorders has been a foundation for psychiatric classification for more than 100 years. Studies directly comparing Schizophrenia (SZ) and Bipolar Disorder with psychotic features (BDp) provide a valuable test of Kraepelin's model of specificity. While some results comparing the psychotic form of BD with schizophrenia support the Kraepelinian dichotomy (Arnone et al. 2009), others support the unitary or continuum concept of psychosis, which posits the two psychotic illnesses arise from common neurobi-ological processes (Van Snellenberg and de Candia 2009).