Effect of Artemisia sieberi or Terbinafine 1% onTrichophyton mentagrophytes infection in Guinea pigs

摘要

Effects of Artemisia sieberi essence or Terbinafine 1% cream onexperimental dermatophytosis caused by Trichophyton mentagrophytes in guinea pigs aredescribed. Standard protocol M38-A (CLSI) was used to determine minimum inhibitoryconcentration (MIC) of 1.1mug/mL for Artemisia sieberi essence. Groups of 6 guinea pigs eachwere treated after day 5 of infection every 12 hours with Terbinafine 1% cream or A. sieberiessence. Controls were non-treated infected and non-infected non-treated guinea pigs. Pigswere evaluated clinically and by laboratory tests recorded in SPSS. By 6 weeks, Artemisiasieberi and Terbinafine had reduced fungal infections 100 and ~67%, respectively (p<0.05).Results suggested that Artemisia sieberi essence may treat Trichophyton mentagrophytesdermatophytosis.