A zinc-catalyzed oxidative reaction of ynamides with phenols and thiophenols: highly site-selective synthesis of versatile α-aryloxy amides and α-arylthio amides

摘要

A zinc-catalyzed oxidative reaction of ynamides with phenols and thiophenols under mild reaction conditions has been developed, which provides various α-aryloxy amides and α-arylthio amides in moderate to good yields, respectively. Importantly, high chemoselectivity is achieved by such a non-noble metalcatalyzed alkyne oxidation.