Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs

Dai M. -W.; Chu J. -G.; Tian F. -M.; Song H. -P.; Wang Y.; Zhang Y. -Z.; Zhang L.

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Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs

机译：甲状旁腺激素（1-34）在半月板切除的豚鼠软骨代谢和维持软骨下骨微结构方面比塞来昔布具有更广泛的作用

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摘要

Objective: To evaluate the effects of PTH(1-34) on cartilage, subchondral bone mass and structure in medial meniscectomized guinea pigs and compare them to those of celecoxib (CLX).

机译：目的：评价PTH（1-34）对内侧半月板切除的豚鼠软骨，软骨下骨量和结构的影响，并将其与塞来昔布（CLX）进行比较。

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《Osteoarthritis and cartilage》 |2016年第6期|共10页
作者
Dai M. -W.; Chu J. -G.; Tian F. -M.; Song H. -P.; Wang Y.; Zhang Y. -Z.; Zhang L.;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Osteoarthritis; PTH(1-34); Celecoxib; Cartilage; Subchondral bone; micro-CT;

机译：骨关节炎;PTH（1-34）;塞来昔布;软骨;软骨下骨;微型CT;

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专利

1. Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs [J] . Dai M. -W., Chu J. -G., Tian F. -M., Osteoarthritis and cartilage . 2016,第6期

机译：甲状旁腺激素（1-34）在半月板切除的豚鼠软骨代谢和维持软骨下骨微结构方面比塞来昔布具有更广泛的作用
2. The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model [J] . Li-tao Shao, Yu Gou, Jia-kang Fang, Orthopaedic surgery . 2021,第5期

机译：通过胶原酶诱导的骨关节炎小鼠模型下对软骨和子骨骨甲状旁腺激素（1-34）通过降低jak2 / stat3和wnt5a / ror2的保护作用
3. Quantitative assessment of articular cartilage and subchondral bone histology in the meniscectomized guinea pig model of osteoarthritis. [J] . Pastoureau P, Leduc S, Chomel A, Osteoarthritis and cartilage . 2003,第6期

机译：在半月板切除的豚鼠骨关节炎模型中对关节软骨和软骨下骨组织学进行定量评估。
4. Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis [C] . Helen L. Quasnichka, Janet M. Anderson-Mac Kenzi International Symposium on Mechanobiology of Cartilage and Chondrocyte . 2006

机译：豚鼠骨关节炎的软骨降解后骨髓性骨和韧带改变
5. Lactational changes in bone metabolism in mice lacking parathyroid hormone (PTH). [D] . Buckle, Kerri Lorraine. 2006

机译：缺乏甲状旁腺激素（PTH）的小鼠骨骼代谢的乳酸变化。
6. The Protective Effects of Parathyroid Hormone (1‐34) on Cartilage and Subchondral Bone Through Down‐Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase‐Induced Osteoarthritis Mouse Model [O] . Li‐tao Shao, Yu Gou, Jia‐kang Fang, 2021

机译：甲状旁腺激素（1-34）对软骨和骨髓内骨的保护作用通过胶原酶诱导的骨关节炎小鼠模型下调JAK2 / Stat3和WNT5A / RO2
7. Parathyroid hormone (1-34) prevents cartilage degradation and preserves subchondral bone micro-architecture in guinea pigs with spontaneous osteoarthritis [O] . Yan J.-y., Tian F.-m., Wang W.-Y., 2014

机译：甲状旁腺激素（1-34）预防自发性骨关节炎的豚鼠软骨退化并保留软骨下骨微结构
8. Further Studies on the Intermediary Metabolism of Bone in Vitro and a Monoclonal Cell Line (MMB-1) Derived from Bone: Effects of Parathyroid Hormone and Acetazolamide [R] . Nichols, F. C. 1981

机译：骨源性和单克隆细胞系（mmB-1）中间代谢的进一步研究：甲状旁腺激素和乙酰唑胺的作用

Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs

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