GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition.

L Enochson; J Stenberg; M Brittberg; A Lindahl

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GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition.

机译：GDF5通过DKK1介导的经典Wnt信号传导抑制作用降低人软骨细胞中MMP13的表达。

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Herein, we provide evidence of a previously unknown link between GDF5 signaling and canonical Wnt signaling that may contribute to the understanding of the molecular mechanisms of OA.

机译：在本文中，我们提供了GDF5信号传导和经典Wnt信号传导之间未知链接的证据，该链接可能有助于理解OA的分子机制。

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《Osteoarthritis and cartilage》 |2014年第4期|共12页
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L Enochson; J Stenberg; M Brittberg; A Lindahl;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
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1. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. [J] . L Enochson, J Stenberg, M Brittberg, Osteoarthritis and cartilage . 2014,第4期

机译：GDF5通过DKK1介导的经典Wnt信号传导抑制作用降低人软骨细胞中MMP13的表达。
2. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
3. Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. [J] . Cha SW, Tadjuidje E, Tao Q, Development . 2008,第22期

机译：Wnt5a和Wnt11以母体Dkk1调节的方式相互作用，以激活非洲爪蟾轴形成中的规范和非规范信号。
4. Inhibition of canonical Wnt signaling pathway by DKK1 induces increased ALP activity in hMSC in vitro [C] . Anna Thorfve, Anders Lindahl, Peter Thomsen, World biomaterials congress . 2012

机译：DKK1抑制经典的Wnt信号通路诱导体外hMSC中增加的ALP活性
5. Ryk mediated non-canonical Wnt signaling in the hematopoietic stem cell. [D] . Povinelli, Benjamin J. 2014

机译：Ryk在造血干细胞中介导的非经典Wnt信号传导。
6. Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression [O] . Leilei Zhong, Stefano Schivo, Xiaobin Huang, 2017

机译：一氧化氮通过减少DKK1和FRZB的表达介导白细胞介素1β和WNT信号在原代人软骨细胞之间的串扰。
7. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition [O] . Enochson L., Stenberg J., Brittberg M., 2014

机译：GDF5通过DKK1介导的经典Wnt信号传导抑制作用降低人软骨细胞中MMP13的表达

GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition.

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