Is loss in femorotibial cartilage thickness related to severity of contra-lateral radiographic knee osteoarthritis? - Longitudinal data from the Osteoarthritis Initiative

摘要

Objective: Anti-catabolic disease modifying drugs (DMOADs) aim to reduce cartilage loss in knee osteoarthritis (KOA). Testing such drugs in clinical trials requires sufficient rates of loss in the study participants to occur, preferably at a mild disease stage where cartilage can be preserved. Here we analyze a "progression" model in mild radiographic KOA (RKOA), based on contra-lateral radiographic status.