An Efficient and High-yielding One-pot Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Sodium Hydrogen Carbonate under Solvent-free Conditions

摘要

Sodium hydrogen carbonate, NaHCO3, efficiently catalyzes the one-pot, three-component reaction of phthalhydrazide, an aromatic aldehyde, and malononitrile or ethyl cyanoacetate under solvent-free conditions, to afford the corresponding 1H-pyrazolo[1,2-b]phthalazine-5,10-diones in high yields. Easy work up, inexpensive and readily available catalyst and avoiding the use of harmful organic solvents are other advantages of this simple procedure.