Synthesis of novel 2-amino-4-(4'-methoxy) phenyl-5,10-dihydropyrimido [4',5':5,4]-cyclopent [b] indoles and acetylderivatives of cyclopent [b] indoles

摘要

Mixed aldol reaction of 1-oxo-1,2,3,8-tetrahydrocyclopent[b]indoles (1a-e) with 4-methoxybenzaldehye afforded 2a-e in good yield which were further condensed with guanidine nitrate to produce the titled compounds 2-amino-4-(4'-methoxy) phenyl-5,10-dihydropyrimidol[4',5':5,4]cyclopent [b] indoles (3a-e).In another attempt,the same 1 -oxo-1,2,3,8-tetrahydrocyclopent[6] indoles (1a-d) were treated with a mixture of glacial acetic acid and polyphosphoric acid with an interest to get 5,10-dihydro-2-methyl-4-Qxopyrano[2',3':5,4]cyclopent[b] indoles (5a-d).Instead,acetyl derivatives of 1a-d were obtained.