A general strategy for improving enantiomeric purities via the tandem use of mirror-image catalysts

摘要

In situations where the asymmetric transfer hydrogenation catalysis of a given ketone gives moderate, though insufficiently high ee, the enantiomeric purity of the resulting alcohol can be enhanced via a subsequent asymmetric dehydrogenation with the antipode of the catalyst. Herein, we report on the theoretical and experimental aspects of this strategy. [References: 30]