Selective carbonylation routes to thiocarbamates. An alternative to phosgene

摘要

A new route for the synthesis of thiocarbamates using a transition metal complex and CO as a replacement for phosgene has been discovered. The complex (PPh3)(2)PdCl2 reacts with N-benzylmethylamine, 4-chlorobenzenethiol, and CO to selectively generate a thiocarbamate. Kinetic studies and the isolation of several intermediates in this reaction allow for the proposal of a mechanistic scheme. [References: 33]