Synthesis and 12-Helical Secondary Structure of β-Peptides Containing (2R,3R)-Aminoproline

摘要

(2R,3R)-Aminoproline, a pyrrolidine-based β-amino acid, was synthesized and incorporated into hexa-β-peptide 4. This residue confers water solubility when the ring nitrogen is protonated and allows for 12-helix formation in aqueous solution. Circular dichroism spectra display the 12-helical signature, and 12-helical structure was confirmed by 2D NMR analysis.