A New Phenoxyacetate-Based Linker System for the Solid-Phase Synthesis of Oligosaccharides

摘要

A novel linker system has been designed,and its first application to solid-phase oligosaccharide synthesis is described.The use of the highly reactive o-nitro-phenoxyacetate linker allows a fast and quantitative cleavage using mild basic conditions.This method combined with the trichloroacetimidate glycosylation exhibits highly promising results as demonostrated for the synthesis of tetrasaccharide 1 (n=3) containing glucose #beta#(1->4) and #beta#(1->6) linkages.