Highly effective transition structure designed catalyst for the enantio-and position-selective dihydorxylation of polyisoprenoids

摘要

The chiral monocinchona derivative shown,synthesized in one step from two efficiently prepared chiral building blodks,was designed under mechanistic guidance as a catalyst for the enantio-and position-selective dihydroxylation of the terminal isopropylidene group of polyisoprenoids.Its efficacy as a synthetic reagent for this purpose was demonstrated for several different substrates.