Negishi Coupling between α-Alkyl(aryl)thio Vinyl Zinc Chloride and α-Bromo Vinyl Ether: A Convergent Synthesis of 2-Alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes

摘要

A convergent approach for the stereoselective synthesis of 2-alkoxy-3-alkyl(aryl)thiobuta-1,3-dienes has been developed. It was found that Negishi coupling between α-alkyl(aryl)thio vinyl zinc chloride and α-bromo vinyl ether or Negishi coupling between α-bromo vinyl sulfide and α-alkoxy vinyl zinc chloride provided the best yield and stereoselectivity.