Effect of a 17#alpha#-(3-Hydroxypropyl)-17#beta#-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11#beta#-Arylestra-4,9-dien-3-ones

C.Edgar Cook; Prasad Raje; David Y.-W.Lee; John A.Kepler

首页> 外文期刊>Organic letters >Effect of a 17#alpha#-(3-Hydroxypropyl)-17#beta#-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11#beta#-Arylestra-4,9-dien-3-ones

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Effect of a 17#alpha#-(3-Hydroxypropyl)-17#beta#-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11#beta#-Arylestra-4,9-dien-3-ones

机译：17＃alpha＃-（3-羟丙基）-17＃beta＃-乙酰基取代模式对11＃beta＃-Arylestra-4,9-dien-3-ones的糖皮质激素和孕激素受体结合的影响

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Replacing the 17-acetoxy substituent in an antiprogestational 17#beta#-acetyl-11#beta#-arylestra-4,9-dien-3-one by 3-hydroxypropyl significantly diminishe glucocorticoid receptor binding with little effect on progestin receptor binding

机译：用3-羟丙基取代抗孕的17＃beta＃-乙酰基-11＃beta＃-芳基-4,9-dien-3-one中的17-乙酰氧基取代基显着降低了糖皮质激素受体的结合，而对孕激素受体的结合几乎没有影响

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《Organic letters》 |2001年第7期|共4页
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C.Edgar Cook; Prasad Raje; David Y.-W.Lee; John A.Kepler;
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1. Effect of a 17#alpha#-(3-Hydroxypropyl)-17#beta#-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11#beta#-Arylestra-4,9-dien-3-ones [J] . C.Edgar Cook, Prasad Raje, David Y.-W.Lee, Organic letters . 2001,第7期

机译：17＃alpha＃-（3-羟丙基）-17＃beta＃-乙酰基取代模式对11＃beta＃-Arylestra-4,9-dien-3-ones的糖皮质激素和孕激素受体结合的影响
2. Two unrelated putative membrane-bound progestin receptors, progesterone membrane receptor component 1 (PGMRC1) and membrane progestin receptor (mPR) beta, are expressed in the rainbow trout oocyte and exhibit similar ovarian expression patterns [J] . Brigitte Mourot, Thaovi Nguyen, Alexis Fostier, Reproductive Biology and Endocrinology . 2006,第1期

机译：虹鳟卵母细胞中表达了两个无关的假定的膜结合孕激素受体，孕激素膜受体组分1（PGMRC1）和膜孕激素受体（mPR）beta，并表现出相似的卵巢表达模式
3. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. [J] . Attardi BJ, Burgenson J, Hild SA, The Journal of Steroid Biochemistry and Molecular Biology . 2004,第3期

机译：CDB-2914，CDB-4124和米非司酮的假定代谢产物和合成衍生物的体外抗孕激素/抗糖皮质激素活性以及孕激素和糖皮质激素受体的结合。
4. The cloning and expression of the ligand-binding domains of glucocorticoid and estrogen receptors. [D] . Xu, Yan. 2009

机译：糖皮质激素和雌激素受体的配体结合域的克隆和表达。
5. Distinction between progestin- and glucocorticoid-binding sites in mammary glands. Apparent lack of cytoplasmic progesterone receptors in lactating mammary glands. [O] . G Shyamala, W A McBlain 1979

机译：乳腺中孕激素和糖皮质激素结合位点之间的区别。哺乳性乳腺中明显缺乏细胞质孕激素受体。
6. Distinction between progestin- and glucocorticoid-binding sites in mammary glands. Apparent lack of cytoplasmic progesterone receptors in lactating mammary glands. [O] . Shyamala, G, McBlain, W A 1979

机译：乳腺中孕激素和糖皮质激素结合位点之间的区别。哺乳性乳腺中明显缺乏细胞质孕激素受体。
7. Temporal Patterns of Mammary Epithelial Cell Gene Expression in Response to Glucocorticoid Receptor Activation [R] . Conzen, S. D. 2002

机译：乳糖皮质激素受体激活对乳腺上皮细胞基因表达的时间模式

Effect of a 17#alpha#-(3-Hydroxypropyl)-17#beta#-acetyl Substituent Pattern on the Glucocorticoid and Progestin Receptor Binding of 11#beta#-Arylestra-4,9-dien-3-ones

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