Ruthenium Complex-Catalyzed anti-Markovnikov Hydration of Terminal Alkynes

摘要

Highly regioselective,efficient,and substituent-tolerant anti-Markovnikov hydration of terminal alkynes occurs to give n-aldehyde by use of a catalytic amount of easily available cyclopentadienylruthenium complexes bearing appropriate bidentate or monodentate phosphine ligands.Typically,RuCpCl(dppm) (1 mol%) catalyzes the addition of water to 1-hexyne at 100degC to give hexanal in 95% yield: 2-hexanone is not detected at all.