Mg-Promoted Regio- and Stereoselective C-Acylation of Aromatic #alpha#,#beta#-Unsaturated Carbonyl Compounds

摘要

Treatment of aromatic #alpha#,#beta#-unsaturated carbonyl compounds with Mg turnings inthe presence of acid anhydrides/TMSCl or acyl chlorides in DMF brought about a facile and efficient cross-coupling to give C-acylation products, which are useful 1,4-dicarbonyl compounds, ingood to excellent yields in a regio- and stereoselective manner. The reaction may be initiated by electron transfer from magnesium to the substrates.