2'-Deoxyguanosine (DG) Oxidation and Strand-Break Formation in DNA by the Radicals Released in the Photolysis of N-tert-Butoxy-2-pyridone. Are tert-Butoxyl or Methyl Radicals Responsible for the Photooxidative Damage in Aqueous Media?

Waldemar Adam; Stefan Marquardt; Diana Kemmer; Chantu R. Saha-Moller; Peter Schreier

首页> 外文期刊>Organic letters >2'-Deoxyguanosine (DG) Oxidation and Strand-Break Formation in DNA by the Radicals Released in the Photolysis of N-tert-Butoxy-2-pyridone. Are tert-Butoxyl or Methyl Radicals Responsible for the Photooxidative Damage in Aqueous Media?

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2'-Deoxyguanosine (DG) Oxidation and Strand-Break Formation in DNA by the Radicals Released in the Photolysis of N-tert-Butoxy-2-pyridone. Are tert-Butoxyl or Methyl Radicals Responsible for the Photooxidative Damage in Aqueous Media?

机译：N'-叔-丁氧基-2-吡啶酮的光解反应中释放出的自由基会导致DNA中的2'-脱氧鸟苷（DG）氧化和链断裂。叔丁氧基或甲基自由基对水介质中的光氧化损伤负责吗？

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The photolysis of pyridone 3b (photo-Fenton reagent) in benzene releases tert-butoxyl radicals, which have been trapped by DMPO and EPR-spectrally identified. In aqueous solution, however, the fragmentation of the tert-butoxyl into methyl radicals prevails and the former radicals are of no direct consequence in the photooxidation of 2'-deoxyguanosine (dG) and pBR 322 DN. The photooxidative damage of nucleic acids is caused by the oxyl reaical species generated from the methyl radicals with oxygen.

机译：吡啶酮3b（光芬顿试剂）在苯中的光解会释放叔丁氧基，这些自由基已被DMPO捕获并通过EPR光谱鉴定。然而，在水溶液中，叔丁氧基裂解成甲基自由基占主导，而前者自由基对2'-脱氧鸟苷（dG）和pBR 322 DN的光氧化没有直接影响。核酸的光氧化损伤是由甲基自由基与氧产生的羟基自由基物质引起的。

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《Organic letters》 |2002年第2期|共4页
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Waldemar Adam; Stefan Marquardt; Diana Kemmer; Chantu R. Saha-Moller; Peter Schreier;
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1. 2'-Deoxyguanosine (DG) Oxidation and Strand-Break Formation in DNA by the Radicals Released in the Photolysis of N-tert-Butoxy-2-pyridone. Are tert-Butoxyl or Methyl Radicals Responsible for the Photooxidative Damage in Aqueous Media? [J] . Waldemar Adam, Stefan Marquardt, Diana Kemmer, Organic letters . 2002,第2期

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2'-Deoxyguanosine (DG) Oxidation and Strand-Break Formation in DNA by the Radicals Released in the Photolysis of N-tert-Butoxy-2-pyridone. Are tert-Butoxyl or Methyl Radicals Responsible for the Photooxidative Damage in Aqueous Media?

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